AstraZeneca's Imfinzi Shows Promise in Bladder Cancer Trials

Published 9 hours agoAZN

AstraZeneca's Imfinzi Shows Promise in Bladder Cancer Trials

AstraZeneca's Imfinzi (durvalumab) has delivered promising results in recent trials for treating muscle-invasive bladder cancer. The NIAGARA Phase III trial demonstrated that combining Imfinzi with neoadjuvant chemotherapy, administered before and after bladder removal surgery, significantly improved patient survival outcomes. Notably, the trial reported an event-free survival (EFS) rate of 67.8% at 24 months for patients receiving the combined regimen, compared to 59.8% for those on chemotherapy alone.

The trial also highlighted an improvement in overall survival (OS) rates, with the Imfinzi group achieving an 82.2% OS at 24 months versus 75.2% for the chemotherapy-only group. Reuters reported that the Imfinzi regimen reduced the risk of disease progression or death by 32% and cut the risk of death by 25% when compared to standard chemotherapy treatment.

AstraZeneca unveiled these findings at the 2024 European Society for Medical Oncology Congress. They emphasized that using Imfinzi perioperatively could be a significant step forward in fighting muscle-invasive bladder cancer. With these results, Imfinzi not only improves patient outcomes but also underscores AstraZeneca's commitment to developing innovative cancer therapies.

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